Role of RGM coreceptors in bone morphogenetic protein signaling

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Role of RGM coreceptors in bone morphogenetic protein signaling

BACKGROUND The repulsive guidance molecule (RGM) proteins, originally discovered for their roles in neuronal development, have been recently identified as co-receptors in the bone morphogenetic protein (BMP) signaling pathway. BMPs are members of the TGFbeta superfamily of signaling cytokines, and serve to regulate many aspects of cellular growth and differentiation. RESULTS Here, we investig...

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Bone Morphogenetic Protein Signaling: Implications in Urology

The bone morphogenetic proteins (BMPs), as members of the transforming growth factor-beta (TGF-beta) superfamily, not only control bone formation, but also regulate multiple key steps during embryonic development and differentiation. Furthermore, BMPs play critical roles in maintaining the homeostasis of the cardiovascular, pulmonary, reproductive, urogenital, and nervous systems in adult life....

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TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling.

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Activation of vascular bone morphogenetic protein signaling in diabetes mellitus.

RATIONALE Diabetes mellitus is frequently complicated by cardiovascular disease, such as vascular calcification and endothelial dysfunction, which have been associated with bone morphogenetic proteins (BMPs). OBJECTIVE To determine whether hyperglycemia in vitro and diabetes in vivo promote vascular BMP activity and correlate with vascular calcification. METHODS AND RESULTS Increased glucos...

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ژورنال

عنوان ژورنال: Journal of Molecular Signaling

سال: 2007

ISSN: 1750-2187

DOI: 10.1186/1750-2187-2-4